Publications

01 December 2018

How Does an Anti-CTLA-4 Antibody Promote Cancer Immunity?


Authors: Liu Y, Zheng P.
Citation: Trends Immunol. 2018 Dec;39(12):953-956. doi: 10.1016/j.it.2018.10.009.
Products: ONC-392

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Anti-CTLA-4 antibodies can induce lasting protection for some melanoma patients. However, their therapeutic potential is limited by significant immunotherapy-related adverse effects (irAE). Here, we argue that the therapeutic effect may be based on an agonist activity that is fundamentally distinct, and can be therapeutically differentiated, from the antagonist activity responsible for irAE.

Last modified on 31 October 2020

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Based in Rockville, Maryland, OncoImmune is a
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treatment of cancer and autoimmune disease.

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