Dr. Guan is an authority in signal transduction in regulation of cell growth, organ size control and tumorigenesis. He demonstrated the role of Tuberous Sclerosis tumor suppressors in cell growth by inhibiting mTOR and contributed to the establishment of the mTOR signaling network. He discovered the signals and receptors for the elusive Hippo/YAP pathway and revealed the biochemical mechanism of it regulation. Dr. Guan was elected as fellow of AAAS in 2008 for his pioneering contribution to cell biology and signal transduction.
Dr. Guan earned his bachelor from Hangzhou University and Ph.D. from Purdue University. He has won Young Investigator Award from American Society of Biochemistry and Molecular Biology; MacArthur Fellow from the MacArthur Foundation; Distinguished Alumni Award from Purdue University. Dr. Guan is a highly cited researcher in molecular biology and genetics (Thomson Reuter).